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Danny Tam

Exelixis

24

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The irreversible covalent fibroblast growth factor receptor inhibitor PRN1371 exhibits sustained inhibition of FGFR after drug clearance

2017 Molecular Cancer Therapeutics
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THU0068 Preclinical Characterization of PRN1008, a Novel Reversible Covalent Inhibitor of BTK that Shows Efficacy in a RAT Model of Collagen-Induced Arthritis

2015 Annals of the Rheumatic Diseases
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SAT0232 A Phase 1 Clinical Trial of PRN1008, an Oral, Reversible, Covalent BTK Inhibitor Demonstrates Clinical Safety and Therapeutic Levels of BTK Occupancy Without Sustained Systemic Exposure

2015 Annals of the Rheumatic Diseases
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Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors

2013 Bioorganic & Medicinal Chemistry Letters
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Crystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes

2013
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Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors

2013 Bioorganic & Medicinal Chemistry Letters
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Selective and Brain‐Permeable Polo‐like Kinase‐2 (Plk‐2) Inhibitors That Reduce α‐Synuclein Phosphorylation in Rat Brain

2013 ChemMedChem
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Discovery and characterization of an inhibitor of glucosylceramide synthase.

2012 Journal of Medicinal Chemistry
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Chemoproteomics-Based Design of Potent LRRK2-Selective Lead Compounds That Attenuate Parkinson’s Disease-Related Toxicity in Human Neurons

2011 ACS Chemical Biology
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Inhibition of Tumor Cell Growth, Invasion, and Metastasis by EXEL-2880 (XL880, GSK1363089), a Novel Inhibitor of HGF and VEGF Receptor Tyrosine Kinases

2009 Cancer Research
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Citations (261)