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Hing L. Sham

Thermo Fisher Scientific

214

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Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors

2013 Bioorganic & Medicinal Chemistry Letters
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Synthesis of Novel Tetrahydro-1H-pyrazolo[4,3-c]pyridines (V) via Intramolecular Nitrilimine Cycloaddition.

2013 ChemInform
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Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors

2013 Bioorganic & Medicinal Chemistry Letters
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Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors

2013 Bioorganic & Medicinal Chemistry Letters
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Selective and Brain‐Permeable Polo‐like Kinase‐2 (Plk‐2) Inhibitors That Reduce α‐Synuclein Phosphorylation in Rat Brain

2013 ChemMedChem
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Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.

2011 Bioorganic & Medicinal Chemistry Letters
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Highly Selective c-Jun N-Terminal Kinase (JNK) 2 and 3 Inhibitors with In Vitro CNS-like Pharmacokinetic Properties

2011
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Neuropathology associated with administration of a nonselective beta secretase (BACE) and cathepsin D inhibitor in Mdr 1a/b knockout mice

2011 Alzheimers & Dementia
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Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement.

2011 Bioorganic & Medicinal Chemistry Letters
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Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.

2011 Bioorganic & Medicinal Chemistry Letters
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Citations (38)