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Angelina Bisconte

Genentech

16

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406

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Preclinical Efficacy and Anti-Inflammatory Mechanisms of Action of the Bruton Tyrosine Kinase Inhibitor Rilzabrutinib for Immune-Mediated Disease.

2021 Journal of Immunology
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Open trial of Bruton's tyrosine kinase inhibitor (PRN1008) in the treatment of canine pemphigus foliaceus.

2020 Veterinary Dermatology
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Efficacy of a Bruton’s Tyrosine Kinase Inhibitor (PRN‐473) in the treatment of canine pemphigus foliaceus

2020 Veterinary Dermatology
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Oncogenic activation of JAK3-STAT signaling confers clinical sensitivity to PRN371, a novel selective and potent JAK3 inhibitor, in natural killer/T-cell lymphoma

2018 Leukemia
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PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen‐1 signalling

2018 British Journal of Pharmacology
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A new treatment for autoimmune blistering diseases- the efficacy of Bruton's tyrosinase kinase inhibitor PRN473 in canine pemphigus foliaceus

2016
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THU0068 Preclinical Characterization of PRN1008, a Novel Reversible Covalent Inhibitor of BTK that Shows Efficacy in a RAT Model of Collagen-Induced Arthritis

2015 Annals of the Rheumatic Diseases
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Efficacy in collagen induced arthritis models with a selective, reversible covalent Bruton’s tyrosine kinase inhibitor PRN473 is driven by durable target occupancy rather than extended plasma exposure (THER5P.904)

2015 Journal of Immunology
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Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) and Resting Lymphocyte Kinase (RLK) Using a Novel Covalent Inhibitor PRN694

2014 Blood
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Identification of GNE-293, a potent and selective PI3Kδ inhibitor: navigating in vitro genotoxicity while improving potency and selectivity.

2013 Bioorganic & Medicinal Chemistry Letters
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Citations (24)