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Gary D. Probst

Millennium Pharmaceuticals

32

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Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors

2013 Bioorganic & Medicinal Chemistry Letters
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Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors

2013 Bioorganic & Medicinal Chemistry Letters
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Small-molecule BACE1 inhibitors: a patent literature review (2006 – 2011)

2012 Expert Opinion on Therapeutic Patents
- Gary D. Probst
- Ying-Zi Xu
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Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.

2011 Bioorganic & Medicinal Chemistry Letters
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Highly Selective c-Jun N-Terminal Kinase (JNK) 2 and 3 Inhibitors with In Vitro CNS-like Pharmacokinetic Properties

2011
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Neuropathology associated with administration of a nonselective beta secretase (BACE) and cathepsin D inhibitor in Mdr 1a/b knockout mice

2011 Alzheimers & Dementia
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Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.

2011 Bioorganic & Medicinal Chemistry Letters
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Design and Synthesis of a Novel, Orally Efficacious Tri-substituted Thiophene Based JNK Inhibitor

2011
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Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.

2011 Bioorganic & Medicinal Chemistry Letters
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Pharmacokinetic and pharmacodynamic investigation of ELND006, a novel APP-selective gamma-secretase inhibitor, on amyloid-β concentrations in the brain, CSF and plasma of multiple nonclinical species following oral administration

2010 Alzheimers & Dementia
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