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Jens-Oliver Funk

University of Erlangen-Nuremberg

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Abstract 2091: PRN1371, an irreversible, covalent inhibitor of FGFR1-4 exhibits sustained pathway inhibition in cancer cell lines

2017 Cancer Research
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The irreversible covalent fibroblast growth factor receptor inhibitor PRN1371 exhibits sustained inhibition of FGFR after drug clearance

2017 Molecular Cancer Therapeutics
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A phase 1, multicenter, dose-escalation study of PRN1371, an irreversible covalent FGFR1-4 kinase inhibitor, in patients with advanced solid tumors, followed by expansion cohorts in patients with FGFR genetic alterations.

2016 Journal of Clinical Oncology
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Abstract 1249: PRN1371, an irreversible, covalent inhibitor of FGFR1, 2, 3 and 4 is highly efficacious in preclinical tumor models

2016 Cancer Research
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THU0068 Preclinical Characterization of PRN1008, a Novel Reversible Covalent Inhibitor of BTK that Shows Efficacy in a RAT Model of Collagen-Induced Arthritis

2015 Annals of the Rheumatic Diseases
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Efficacy in collagen induced arthritis models with a selective, reversible covalent Bruton’s tyrosine kinase inhibitor PRN473 is driven by durable target occupancy rather than extended plasma exposure (THER5P.904)

2015 Journal of Immunology
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Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) and Resting Lymphocyte Kinase (RLK) Using a Novel Covalent Inhibitor PRN694

2014 Blood
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Multiple disseminated large-cell acanthomas of the skin associated with human papillomavirus type 6

2011
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Neuronal cell cycle re-entry mediates Alzheimer disease-type changes.

2007 Biochimica et Biophysica Acta
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Cell Cycle Checkpoint Genes and Cancer

2006
- Jens-Oliver Funk
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