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Clive Mccarthy

Novartis

39

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413

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WS17.4 ETD001: a long-acting and safely inhaled ENaC blocker to enhance mucociliary clearance

2020 Journal of Cystic Fibrosis
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TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis

2020 American Journal of Respiratory and Critical Care Medicine
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Abstract A94: Identification of potent, insurmountable A2a antagonists for modulation of the tumor microenvironment

2020
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ePS1.08 A systematic comparison of the profiles of inhaled ENaC blocker candidates on mucociliary clearance: are we under-dosing in clinical studies?

2019 Journal of Cystic Fibrosis
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Abstract 5014: Profile of ARX001822, a highly potent, selective and orally bioavailable A2a antagonist effective in preventing adenosinergic suppression of T cell activation

2019 Cancer Research
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Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors

2016 Bioorganic & Medicinal Chemistry Letters
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Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD).

2015 Journal of Medicinal Chemistry
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The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist

2014 Bioorganic & Medicinal Chemistry Letters
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Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors.

2011 Bioorganic & Medicinal Chemistry Letters
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A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients

2011 Cancer Research
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Citations (93)