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Sébastien Jeay

Novartis

45

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1170

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First-in-Human, Phase I Dose-Escalation Study of CGM097, a HDM2 Inhibitor in Adult Patients With p53 Wild-type Advanced Solid Malignancies

2021
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Pharmacokinetic-pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies.

2021 British Journal of Cancer
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Predictive Power of Time-Series Based Machine Learning Models for DMPK Measurements in Drug Discovery

2019 ICANN | International Conference on Artificial Neural Networks
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In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor.

2018 Bioorganic & Medicinal Chemistry Letters
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Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53–MDM2 Inhibitor HDM201

2018 Cancer Research
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Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf−/− mouse model

2017 Proceedings of the National Academy of Sciences of the United States of America
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Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human ALK mutant neuroblastoma cell lines and xenograft models

2017 eLife
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Abstract 4855: Discovery of NVP-HDM201 - First disclosure of a Next-Generation Mdm2 inhibitor with superior characteristics

2016 Cancer Research
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Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma

2016 European Journal of Cancer
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Supplementary Material for: The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1

2016
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