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Andrew R. Tuffnell

Novartis

6

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Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD).

2015 Journal of Medicinal Chemistry
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The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist

2014 Bioorganic & Medicinal Chemistry Letters
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A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of β2-adrenoceptor agonists as inhaled long-acting bronchodilators

2010 Bioorganic & Medicinal Chemistry Letters
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A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential

2005 Bioorganic & Medicinal Chemistry Letters
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