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Felix Rohdich

Merck KGaA

35

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670

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Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models.

2021 Journal of Medicinal Chemistry
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Using thrombocytopenia modeling to investigate the mechanisms underlying platelet depletion induced by pan-proteasome inhibitors.

2021
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Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (β5i).

2021 Journal of Medicinal Chemistry
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M3258 is a selective inhibitor of the immunoproteasome subunit LMP7 (β5i) delivering efficacy in multiple myeloma models.

2021 Molecular Cancer Therapeutics
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A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors

2019 Scientific Reports
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Abstract DDT02-01: First-time disclosure of M3258: A selective inhibitor of the immunoproteasome subunit LMP7 with potential for improved therapeutic utility in multiple myeloma compared to pan-proteasome inhibitors

2019 Cancer Research
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Abstract LB-054: Discovery and profiling of M3258, a potent and selective LMP7 inhibitor demonstrating high efficacy in multiple myeloma models

2019 Cancer Research
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Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates

2017 Bioorganic & Medicinal Chemistry Letters
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2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19.

2016 ACS Medicinal Chemistry Letters
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pathway: Metabolic role of l

2016
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