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Jianguo Ma

Merck Serono

11

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30

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Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors

2021 Bioorganic & Medicinal Chemistry Letters
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Abstract DDT02-01: First-time disclosure of M3258: A selective inhibitor of the immunoproteasome subunit LMP7 with potential for improved therapeutic utility in multiple myeloma compared to pan-proteasome inhibitors

2019 Cancer Research
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Abstract LB-054: Discovery and profiling of M3258, a potent and selective LMP7 inhibitor demonstrating high efficacy in multiple myeloma models

2019 Cancer Research
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MEK inhibition leads to BRCA2 downregulation and sensitization to DNA damaging agents in pancreas and ovarian cancer models

2018 Oncotarget
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Abstract 2603: Combination activity of the MEK inhibitor Pimasertib and the hypoxia-activated prodrug TH-302 in pancreatic and biliary tract tumor xenograft models

2015 Cancer Research
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Abstract 4638: Anti-tumor activity of pimasertib in combination with SAR245409 or SAR245408 in human primary colorectal cancer xenograft models bearing PI3K/KRas and KRas mutations.

2013 Cancer Research
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Abstract A162: Identification of brain penetrant p70S6K/Akt inhibitor MSC2363318A.

2013 Molecular Cancer Therapeutics
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Abstract LB-456: Evaluation of brain pharmacokinetics as a potential differentiation factor for the MEK inhibitors, MSC2015103 and pimasertib

2012 Cancer Research
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Abstract LB-208: Hijacking the PI3K/mTor and KRas/MEK/ERK signaling pathways with a therapeutic assault results in robust antitumor activity in PI3K/KRas and KRas mutant tumors

2011 Cancer Research
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