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Daniel Schwarz

Goethe University Frankfurt

28

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1702

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Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies

2019 Bioorganic & Medicinal Chemistry Letters
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2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19.

2016 ACS Medicinal Chemistry Letters
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Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore

2016 Bioorganic & Medicinal Chemistry Letters
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Abstract 3025: Discovery of preclinical development candidate inhibitors of the mediator complex-associated kinases CDK8 and CDK19 and evaluation of their therapeutic potential

2016 Cancer Research
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Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease

2015 Journal of Medicinal Chemistry
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A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease

2015 Nature Chemical Biology
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Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease.

2014 Journal of Medicinal Chemistry
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Structural Basis for Tail-Anchored Membrane Protein Biogenesis by the Get3-Receptor Complex

2011 Science
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Cell-free expression and stable isotope labelling strategies for membrane proteins.

2010 Journal of Biomolecular NMR
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Membrane Protein Expression in Cell-Free Systems

2010 Methods of Molecular Biology
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Citations (61)