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Paul A. Clarke

Institute of Cancer Research

170

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DFT data for "Enantioselective “clip-cycle” synthesis of di-, tri- and spiro- substituted tetrahydropyrans"

2021
- Kristaps Ermanis
- Paul A. Clarke
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Evolution of kinase polypharmacology across HSP90 drug discovery.

2021 Chemistry & Biology
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Evolution of Kinase Polypharmacology Across HSP90 Drug Discovery

2021
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A PI3K- and GTPase-independent Rac1-mTOR mechanism mediates MET-driven anchorage-independent cell growth but not migration.

2020 Science Signaling
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DFT calculation Data From the Computational Investigations of Asymmetric ‘Clip-Cycle’ Synthesis of Pyrrolidines and Spiropyrrolidines.

2020
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Orally-bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma

2020
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Evolution of kinase polypharmacology across HSP90 drug discovery

2020 bioRxiv
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Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer.

2020 PLOS ONE
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A genome-scale CRISPR screen identifies the ERBB and mTOR signalling networks as key determinants of response to PI3K inhibition in pancreatic cancer.

2020 Molecular Cancer Therapeutics
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Signalling involving MET and FAK supports cell division independent of the activity of the cell cycle-regulating CDK4/6 kinases

2019 bioRxiv
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