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Sondra L. Downey-Kopyscinski

Harvard University
Broad Institute

19

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13

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Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins.

2021 Cell Reports
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M3258 is a selective inhibitor of the immunoproteasome subunit LMP7 (β5i) delivering efficacy in multiple myeloma models.

2021 Molecular Cancer Therapeutics
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Use of Olfactory Receptor Genes As Controls for Genome-Scale CRISPR Functional Genomic Studies to Define Treatment Resistance Mechanisms

2020 Blood
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Functional Genomic Characterization of Endoplasmic Reticulum-Associated Dependencies in Multiple Myeloma - Biologic and Therapeutic Implications

2020 Blood
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Abstract 1936: Immunoproteasome inhibitors for the treatment of ALL

2020
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Mechanisms Regulating Myeloma Cell Responsiveness to Antisense Oligonucleotides Targeting IRF4

2020 Blood
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POU2AF1 As a Master Regulator of Oncogenic Transcription Factor Networks in Myeloma

2020 Blood
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Combinatorial CRISPR-knockout identifies interactions between key genes and regulatory pathways in myeloma

2019 Clinical Lymphoma, Myeloma & Leukemia
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Functional Interactions between Transcription Factors Involved in Myeloma Pathogenesis - Biological and Therapeutic Implications

2019 Blood
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Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins

2019 Blood
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