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Peggy A. Scherle

Bristol-Myers Squibb

12

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217

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Abstract 2919: Discovery of PRT811, a potent, selective, and orally bioavailable brain penetrant PRMT5 Inhibitor for the treatment of brain tumors

2020
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Abstract 2915: Preclinical characterization of PRT543, a potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5), with broad antitumor activity inin vitroandin vivomodels

2020
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Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.

2012 Bioorganic & Medicinal Chemistry Letters
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Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists

2009 Bioorganic & Medicinal Chemistry Letters
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Novel sulfone-containing di- and trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists

2009 Bioorganic & Medicinal Chemistry Letters
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Capped diaminopropionamide–glycine dipeptides are inhibitors of CC chemokine receptor 2 (CCR2)

2007 Bioorganic & Medicinal Chemistry Letters
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Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors

2004 Bioorganic & Medicinal Chemistry Letters
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A new synthesis of cytoxazone and its diastereomers provides key initial SAR information.

2003 Bioorganic & Medicinal Chemistry Letters
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Both 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-Dependent tumor necrosis factor-α antagonists

2003 Bioorganic & Medicinal Chemistry Letters
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