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Dave Rominger
Dave Rominger
Chemistry
Protein arginine methyltransferase 5
Pharmacology
Bioavailability
Penetrant (mechanical, electrical, or structural)
2
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2024
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Abstract 2919: Discovery of PRT811, a potent, selective, and orally bioavailable brain penetrant PRMT5 Inhibitor for the treatment of brain tumors
2020
Yang Zhang
Hong Lin
Min Wang
Dimitrios Angelis
Michael Hawkins
Dave Rominger
Tom Emm
Juan I. Luengo
Bruce Ruggeri
Peggy A. Scherle
Kris Vaddi
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Abstract 2915: Preclinical characterization of PRT543, a potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5), with broad antitumor activity inin vitroandin vivomodels
2020
Neha Bhagwat
Yang Zhang
Hong Lin
Min Wang
Dave Rominger
Tom Emm
Divya Chugani-Mahtani
Dimitrios Angelis
Rupa Shetty
Raul Leal
William Gowen-MacDonald
Alexander Grego
Juan I. Luengo
Taghi Manshouri
Friederike Pastore
Ross L. Levine
Srdan Verstovsek
Bruce Ruggeri
Peggy A. Scherle
Kris Vaddi
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