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Kris Vaddi

Incyte

85

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Abstract 1138: PRMT5 inhibition downregulates MYB and NOTCH1 signaling, key molecular drivers of adenoid cystic carcinoma

2021
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Abstract 1137: PRMT5 inhibition regulates alternative splicing and DNA damage repair pathways in SF3B1 R625G expressing uveal melanoma cells

2021
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Abstract 983: Preclinical characterization of PRT1419, a potent, selective and orally available inhibitor of MCL1

2021
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Abstract 2919: Discovery of PRT811, a potent, selective, and orally bioavailable brain penetrant PRMT5 Inhibitor for the treatment of brain tumors

2020
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PRMT5 inhibition modulates E2F1 methylation and gene regulatory networks leading to therapeutic efficacy in JAK2V617F mutant MPN

2020 Cancer Discovery
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Abstract 2915: Preclinical characterization of PRT543, a potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5), with broad antitumor activity inin vitroandin vivomodels

2020
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FINAL REPORT: CLINICAL STUDY OF ORAL ARSENIC TRIOXIDE CAPSULE FORMULATION, ORH-2014, DEMONSTRATING HIGH BIOAVAILABILITY, GOOD SAFETY AND TOLERABILITY IN PATIENTS WITH ADVANCED HEMATOLOGIC DISORDERS: PS1037

2019
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Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies

2018 PLOS ONE
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INCB040093 is a novel PI3Kδinhibitor for the treatment of B cell lymphoid malignancies

2018 Journal of Pharmacology and Experimental Therapeutics
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The Role of the JAK/STAT Signalling Pathway in Immunoregulation of Gastrointestinal Cancers

2017
- Kris Vaddi
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