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Muthiah Manoharan

Alnylam Pharmaceuticals
Isis Pharmaceuticals

307

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26626

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siRNAs containing 2'-fluorinated Northern-methanocarbacyclic (2'-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2'-F-NMC NTPs.

2021 Nucleic Acids Research
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Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo.

2021 Nucleic Acids Research
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Centyrin ligands for extrahepatic delivery of siRNA.

2021 Molecular Therapy
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Development of lipidoid nanoparticles for siRNA delivery to neural cells

2021 bioRxiv
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INCIDENCE OF DEEP VEIN THROMBOSIS IN HIP ARTHROPLASTY POST MULTIMODAL PROPHYLAXIS

2021
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Expanding the Reach of RNAi Therapeutics with Next Generation Lipophilic siRNA Conjugates

2021
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Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing.

2021 Nucleic Acids Research
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Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.

2021 Nucleic Acids Research
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The Nonclinical Disposition and PK/PD Properties of GalNAc-conjugated siRNA Are Highly Predictable and Build Confidence in Translation to Man.

2021 Drug Metabolism and Disposition
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Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5'-exonuclease.

2020 Nucleic Acids Research
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