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Martin Maier

Alnylam Pharmaceuticals
Isis Pharmaceuticals

108

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7750

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Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo.

2021 Nucleic Acids Research
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Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates.

2020 Nucleic Acids Research
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An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema

2019 RNA
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The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

2019 Nature Nanotechnology
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Reversal of siRNA-mediated gene silencing in vivo

2018 Nature Biotechnology
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Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression

2018 Molecular Therapy
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Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

2018 Molecular Therapy
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Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

2018 Nature Communications
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Facile Synthesis, Geometry, and 2′-Substituent-Dependent in Vivo Activity of 5′-(E)- and 5′-(Z)-Vinylphosphonate-Modified siRNA Conjugates

2018 Journal of Medicinal Chemistry
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Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA

2017 Journal of the American Chemical Society
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