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Muneto Mogi

Novartis

43

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329

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Complement factor B in complex with (S)-5,7-Dimethyl-4-((2-phenylpiperidin-1-yl)methyl)-1H-indole

2020
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Understanding metabolism related differences in ocular efficacy of MGV354.

2020 Xenobiotica
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Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

2020 Journal of Medicinal Chemistry
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Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.

2019 Proceedings of the National Academy of Sciences of the United States of America
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Complement factor D in complex with the inhibitor (S)-2-(2-((3'-(1-amino-2-hydroxyethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)acetic acid

2019
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Complement factor B protease domain in complex with the reversible inhibitor N-(2-bromo-4-methylnaphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amine.

2019
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Complement factor B protease domain in complex with the reversible inhibitor 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid

2019
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Design, synthesis and pre-clinical characterization of selective Factor D inhibitors targeting the alternative complement pathway.

2019 Journal of Medicinal Chemistry
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Complement factor B is necessary for sub-RPE deposit formation in Efemp1R345W/R345W knock-in mice

2019 Investigative Ophthalmology & Visual Science
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Abstract 12892: Safety and Efficacy of LHW090 in Patients With Resistant Hypertension: Results of a Randomized, Double Blind, Parallel Group, Placebo-Controlled Study

2018 Circulation
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