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Karen Anderson

Novartis

28

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134

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Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration.

2021 Investigative Ophthalmology & Visual Science
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Characterization of a model of chronic IOP elevation induced by a photopolymerizable biomatrix

2020 Investigative Ophthalmology & Visual Science
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Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

2020 Journal of Medicinal Chemistry
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Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.

2019 Proceedings of the National Academy of Sciences of the United States of America
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Complement factor B protease domain in complex with the reversible inhibitor N-(2-bromo-4-methylnaphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amine.

2019
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Complement factor B protease domain in complex with the reversible inhibitor 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid

2019
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Design, synthesis and pre-clinical characterization of selective Factor D inhibitors targeting the alternative complement pathway.

2019 Journal of Medicinal Chemistry
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Complement factor B is necessary for sub-RPE deposit formation in Efemp1R345W/R345W knock-in mice

2019 Investigative Ophthalmology & Visual Science
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The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration

2018 Journal of Medicinal Chemistry
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Retinal degeneration and subretinal Iba1+ accumulation in complement factor H-deficient mice are associated with increased gene expression of phagocytic markers

2018 Investigative Ophthalmology & Visual Science
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