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Nicola Hughes

Novartis

10

Papers

206

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Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition.

2021 Journal of Molecular Biology
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Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.

2019 Proceedings of the National Academy of Sciences of the United States of America
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Complement factor B protease domain in complex with the reversible inhibitor N-(2-bromo-4-methylnaphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amine.

2019
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Complement factor B protease domain in complex with the reversible inhibitor 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid

2019
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An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient

2019 Nature Chemical Biology
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Structure-based design and optimization of potent inhibitors of the adenoviral protease.

2015 Bioorganic & Medicinal Chemistry Letters
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Discovery and structure-based optimization of adenain inhibitors.

2014 ACS Medicinal Chemistry Letters
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Structural Determinants of MALT1 Protease Activity.

2012 Journal of Molecular Biology
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Citations (65)