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Mika Endo

Chugai Pharmaceutical Co.

18

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194

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N-(6-phenylpyridazin-3-yl)benzenesulfonamides as highly potent, brain-permeable, and orally active kynurenine monooxygenase inhibitors.

2021 Bioorganic & Medicinal Chemistry Letters
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Exploitation of Elevated Extracellular ATP to Specifically Direct Antibody to Tumor Microenvironment.

2020 Cell Reports
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Abstract 2378: Differential exhaustion on cytokine release (DECREASE) by ERY974, a novel T-cell-redirecting antibody targeting glypican-3: A new type of T-cell exhaustion

2019 Immunology
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Engineering a bispecific antibody with a common light chain: Identification and optimization of an anti-CD3 epsilon and anti-GPC3 bispecific antibody, ERY974

2019 Methods
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Abstract 2747: Anti-glypican-3 monoclonal antibody (codrituzumab/GC33/RO5137382) treatment enhances tumor infiltration of PD-L1-positive macrophages, and combination therapy with anti-PD-L1 monoclonal antibody promotes antitumor effects

2018 Cancer Research
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Procédés de traitement de cancers au moyen d'antagonistes se liant à l'axe pd-1 et d'anticorps anti-gpc3

2017
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An anti–glypican 3/CD3 bispecific T cell–redirecting antibody for treatment of solid tumors

2017 Science Translational Medicine
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Abstract 3653: Combining ERY974, a novel T cell-redirecting bispecific antibody targeting glypican-3, with chemotherapy profoundly improved antitumor efficacy over its monotherapy in xenograft model

2017 Cancer Research
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A water soluble prodrug of a novel camptothecin analog is efficacious against breast cancer resistance protein-expressing tumor xenografts

2010 Cancer Chemotherapy and Pharmacology
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Synthesis and biological activities of a pH-dependently activated water-soluble prodrug of a novel hexacyclic camptothecin analog.

2009 Bioorganic & Medicinal Chemistry Letters
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