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Shunsuke Nagao

Chugai Pharmaceutical Co.

10

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129

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Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist.

2020 Proceedings of the National Academy of Sciences of the United States of America
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EOS789, a novel pan-phosphate transporter inhibitor, is effective for the treatment of chronic kidney disease– mineral bone disorder.

2020 Kidney International
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OWL833, an Orally Active Nonpeptide GLP-1 Receptor Agonist, Improves Glucose Tolerance by Increasing Insulin Secretion and Reduces Food Intake of Cynomolgus Monkeys

2018 Diabetes
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Preclinical evaluation of the potential for cytochrome P450 inhibition and induction of the selective ALK inhibitor, alectinib.

2017 Xenobiotica
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In vitro profiling of the metabolism and drug–drug interaction of tofogliflozin, a potent and highly specific sodium-glucose co-transporter 2 inhibitor, using human liver microsomes, human hepatocytes, and recombinant human CYP

2015 Xenobiotica
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A water soluble prodrug of a novel camptothecin analog is efficacious against breast cancer resistance protein-expressing tumor xenografts

2010 Cancer Chemotherapy and Pharmacology
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Synthesis and biological activities of a pH-dependently activated water-soluble prodrug of a novel hexacyclic camptothecin analog.

2009 Bioorganic & Medicinal Chemistry Letters
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The Novel Formulation Design of Self-emulsifying Drug Delivery Systems (SEDDS) Type O/W Microemulsion I: Enhancing Effects on Oral Bioavailability of Poorly Water Soluble Compounds in Rats and Beagle Dogs

2005 Drug Metabolism and Pharmacokinetics
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Citations (33)