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Asako Harada

Chugai Pharmaceutical Co.

19

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225

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In vitro toxicological support to establish specification limit for anti-CD3 monospecific impurity in a bispecific T cell engager drug, ERY974.

2020 Toxicology in Vitro
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High-content imaging analyses of γH2AX-foci and micronuclei in TK6 cells elucidated genotoxicity of chemicals and their clastogenic/aneugenic mode of action

2019 Genes and Environment
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Advantages of evaluating γH2AX induction in non-clinical drug development

2018 Genes and Environment
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Different players generate positive responses in two in vitro cytokine assay formats with aqueous and immobilized TGN1412 analog

2018 Biochemical and Biophysical Research Communications
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Giemsa-stained pseudo-micronuclei in rat skin treated with vitamin D 3 analog, pefcalcitol

2017 Genes and Environment
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An anti–glypican 3/CD3 bispecific T cell–redirecting antibody for treatment of solid tumors

2017 Science Translational Medicine
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Is an in vitro whole blood cytokine assay useful to detect the potential risk of severe infusion reaction of monoclonal antibody pharmaceuticals

2016 Journal of Toxicological Sciences
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The predominant role of apoptosis in γH2AX formation induced by aneugens is useful for distinguishing aneugens from clastogens

2014 Mutation Research-genetic Toxicology and Environmental Mutagenesis
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New DNA probes to detect aneugenicity in rat bone marrow micronucleated cells by a pan-centromeric FISH analysis.

2013 Mutation Research-genetic Toxicology and Environmental Mutagenesis
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Fluorescent dye-based simple staining for in vivo micronucleus test with flow cytometer.

2013 Mutation Research-genetic Toxicology and Environmental Mutagenesis
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