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Thelma S. Angeles

Cephalon

71

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Development of a Meso Scale Discovery ligand-binding assay for measurement of free (drug-unbound) target in nonhuman primate serum.

2021 Bioanalysis
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Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)

2016 Journal of Medicinal Chemistry
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Recent advances in targeting the fatty acid biosynthetic pathway using fatty acid synthase inhibitors

2016 Expert Opinion on Drug Discovery
- Thelma S. Angeles
- Robert L. Hudkins
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Piperidine-3,4-diol and piperidine-3-ol derivatives of pyrrolo[2,1-f][1,2,4]triazine as inhibitors of anaplastic lymphoma kinase.

2015 Bioorganic & Medicinal Chemistry Letters
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Abstract C272: Antitumor activity of the dual AXL/c-Met inhibitor CEP-40783 in Champions primary TumorGraft™ models of human non-small cell lung cancer (NSCLC).

2013 Molecular Cancer Therapeutics
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A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-A]Pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of Cep-33779.

2012 Journal of Medicinal Chemistry
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Synthesis and Biological Profile of the pan-Vascular Endothelial Growth Factor Receptor/Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor-Like Homology Domains 2 (VEGF-R/TIE-2) Inhibitor 11-(2-Methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (CEP-11981): A Novel Oncology Therapeutic Agent

2012 Journal of Medicinal Chemistry
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Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: Identification of a potent and selective 5-HT6 receptor antagonist showing activity in rat social recognition test

2012 Bioorganic & Medicinal Chemistry Letters
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Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases.

2012 Bioorganic & Medicinal Chemistry Letters
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Discovery of an Orally Efficacious Inhibitor of Anaplastic Lymphoma Kinase

2012 Journal of Medicinal Chemistry
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