Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases.

Craig A. Zificsak,Diane E. Gingrich,Henry J. Breslin,Derek Dunn,Karen L. Milkiewicz,Jay P. Theroff,Tho V. Thieu,Ted L. Underiner,Linda Weinberg,Lisa D. Aimone,Mark S. Albom,Jennifer L. Mason,Lisa Saville,Jean Husten,Thelma S. Angeles,James P. Finn,Mahfuza Jan,Teresa M. OKane,Pawel Dobrzanski,Bruce D. Dorsey

Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases.

2012

Abstract The elaboration of a novel scaffold for the inhibition of JAK2 and FAK kinases was targeted in order to provide a dual inhibitor that could target divergent pathways for tumor cell progression.

Keywords:

Cell
Cell biology
Kinase
Biochemistry
Chemistry
Scaffold
dual inhibitor
dual inhibition
tumor cells

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