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Kyle Powell

Élan

10

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Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.

2011 Bioorganic & Medicinal Chemistry Letters
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Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.

2011 Bioorganic & Medicinal Chemistry Letters
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Design and Synthesis of a Novel, Orally Efficacious Tri-substituted Thiophene Based JNK Inhibitor

2011
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Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System

2009 Journal of Biological Chemistry
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α2β1 and αVβ1 integrin signaling pathways mediate amyloid-β-induced neurotoxicity

2007 Neurobiology of Aging
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Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death

2005 The Journal of Neuroscience
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Methodes d'utilisation de modulateurs de tyrosine kinase 2 riche en proline

2004
- Irene Griswold-Prenner
- Kyle Powell
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Biophysical and kinetic characterization of amyloid-βfibril elongation

2000 Neurobiology of Aging
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Seeded growth of amyloid-$beta;fibrils is critical for amyloid-$beta;neurotoxicity: Implications for the pathogenesis of Alzheimer's disease

2000 Neurobiology of Aging
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