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Wynne Aherne

Institute of Cancer Research

76

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3253

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Correction: A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.

2020 Oncogene
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Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen

2015 Journal of Medicinal Chemistry
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Small-Molecule Inhibitors of the Protein Methyltransferase SET7/9 Identified in a High-Throughput Screen

2012 Journal of Biomolecular Screening
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Mechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response.

2012 PLOS ONE
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Serum angiogenic profile of patients with glioblastoma identifies distinct tumor subtypes and shows that TIMP-1 is a prognostic factor

2011 Neuro-oncology
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Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

2011 The EMBO Journal
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CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors

2011 Cancer Research
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Abstract A235: Structure-guided evolution of potent and selective oral inhibitors of CHK1 through scaffold morphing.

2011 Molecular Cancer Therapeutics
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Discovery of 2-(6-{[(6-Fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a Class I Selective Orally Active Histone Deacetylase Inhibitor

2010 Journal of Medicinal Chemistry
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Identification by high-throughput screening of viridin analogs as biochemical and cell-based inhibitors of the cell cycle-regulated Nek2 kinase

2010 Journal of Biomolecular Screening
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