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Paul Brough

Institute of Cancer Research

31

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1817

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Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.

2017 Journal of Medicinal Chemistry
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VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells

2014 Oncotarget
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Abstract B155: VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and demonstrates context-dependent cytotoxicity to cancer cells.

2013 Molecular Cancer Therapeutics
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New derivatives isoindoline or isoquinoline, their process for the preparation and pharmaceutical compositions containing them

2013
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CHAPTER 8:Discovery of NVP-AUY922

2013
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Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.

2012 Bioorganic & Medicinal Chemistry
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Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening

2011 Topics in Current Chemistry
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Preclinical Antitumor Activity of the Orally Available Heat Shock Protein 90 Inhibitor NVP-BEP800

2010 Molecular Cancer Therapeutics
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Preclinical anti-tumor activity of the orally available Hsp90 inhibitor NVP-BEP800

2010
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Combining Hit Identification Strategies: Fragment- Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-D]Pyrimidine Inhibitors of the Hsp90 Molecular Chaperone.

2009 Journal of Medicinal Chemistry
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Citations (144)