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William D. Holmes

Research Triangle Park

17

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The Great Awakening

2014
- William D. Holmes
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Achieving selectivity in a kinase ATP-binding site by targeting a single amino acid

2002
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Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors

2001 Science
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Solution studies of recombinant human stromal-cell-derived factor-1.

2001 Protein Expression and Purification
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Structure of the Tie2 RTK Domain: Self-Inhibition by the Nucleotide Binding Loop, Activation Loop, and C-Terminal Tail

2000 Structure
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Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase.

2000 Journal of Medicinal Chemistry
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Recombinant Human CXC-Chemokine Receptor-4 in Melanophores Are Linked to Gi Protein: Seven Transmembrane Coreceptors for Human Immunodeficiency Virus Entry into Cells

1998 Molecular Pharmacology
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Dual Inhibition of Human Type 4 Phosphodiesterase Isostates by (R*,R*)-(±)-Methyl 3-Acetyl-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate

1998 Biochemistry
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Detailed Characterization of a Purified Type 4 Phosphodiesterase, HSPDE4B2B: Differentiation of High- and Low-Affinity (R)-Rolipram Binding☆

1997 Protein Expression and Purification
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Human Recombinant Phosphodiesterase 4B2B Binds (R)-Rolipram at a Single Site with Two Affinities

1997 Biochemistry
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