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Robert T. Gampe

GlaxoSmithKline

31

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2935

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A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors

2021 Bioorganic & Medicinal Chemistry Letters
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BacMam production and crystal structure of nonglycosylated apo human furin at 1.89 Å resolution

2019 Acta Crystallographica Section F-structural Biology and Crystallization Communications
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Crystal structure of unglycosylated apo human furin @1.89A

2016
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Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK).

2012 Journal of Medicinal Chemistry
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Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction.

2010 Nature Structural & Molecular Biology
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Structural Analysis of Rev-erbα Bound to NCoR Reveals a Unique Mechanism of Nuclear Receptor-Corepressor Interaction

2010 Nature Structural & Molecular Biology
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Discovery of Tertiary Sulfonamides as Potent Liver X Receptor Antagonists

2010 Journal of Medicinal Chemistry
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Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone.

2007 Journal of Biological Chemistry
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Cathepsin K complexed with a semicarbazone inhibitor

2006
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Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance

2004 Molecular Cell
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Citations (251)