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Victoria B. Knick

Research Triangle Park

16

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2,3,5-Trisubstituted pyridines as selective AKT inhibitors-Part I: Substitution at 2-position of the core pyridine for ROCK1 selectivity.

2010 Bioorganic & Medicinal Chemistry Letters
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Discovery of thiophene inhibitors of polo-like kinase.

2009 Bioorganic & Medicinal Chemistry Letters
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Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor.

2008 Journal of Medicinal Chemistry
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Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors.

2008 Bioorganic & Medicinal Chemistry Letters
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CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor

2008
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Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.

2008 Journal of Medicinal Chemistry
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Identification of GSK461364, a novel small molecule polo-like kinase 1 inhibitor for the treatment of cancer

2007 Cancer Research
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Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity

2007 Molecular Cancer Therapeutics
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Identification of a novel inhibitor of AKT kinase, GSK690693.

2007 Cancer Research
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Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase

2005 Bioorganic & Medicinal Chemistry Letters
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Citations (26)