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Youssef El Ahmad

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Abstract PS17-16: Sar439859, a novel selective estrogen receptor degrader (serd), demonstrates effective and broad antitumor activity in wild-type and mutant er-positive breast cancer models

2021 Cancer Research
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Abstract 3452: Pre-clinical development of next generation selective estrogen receptor degrader - SAR439859

2020
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Optimization and Gram-scale Preparation of S-Trifluoromethyl- Sulfoximines and Sulfilimino iminiums, Powerful Reagents for the Late Stage Introduction of the CF3 Group

2019 Organic Process Research & Development
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Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.

2019 Journal of Medicinal Chemistry
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Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-Yl]-1-(3-Methyl-2-Oxobutyl)-2-(Trifluoromethyl)-3,4-Dihydro-2H-Pyrimido[1,2-A]Pyrimidin-6-One: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors.

2015 Journal of Medicinal Chemistry
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A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

2014 Nature Chemical Biology
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Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers.

2012 Journal of Medicinal Chemistry
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New derivatives of 2,3-dihydro-1h-imidazo {1,2-a} pyrimidin-5-one and 1,2,3,4-tetrahydro-pyrimido {1,2-a} pyrimidin-6-one having a morpholine substituted their preparation and their pharmaceutical use

2012
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Preparation and optimization of new 4-(morpholin-4-yl)-(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives as PI3Kβ inhibitors.

2012 Bioorganic & Medicinal Chemistry Letters
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Pyrimidinone derivatives, their preparation and pharmaceutical use

2011
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