A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

Baptiste Ronan,O. Flamand,Lionel Vescovi,Christine Dureuil,L. Durand,Florence Fassy,Marie-France Bachelot,Annabelle Lamberton,Magali Mathieu,Thomas Bertrand,J. P. Marquette,Youssef El Ahmad,Bruno Filoche-Romme,Laurent Schio,Carlos Garcia-Echeverria,Hélène Goulaouic,Benoit Pasquier

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

2014

Baptiste Ronan
O. Flamand
Lionel Vescovi
Christine Dureuil
L. Durand
Florence Fassy
Marie-France Bachelot
Annabelle Lamberton
Magali Mathieu
Thomas Bertrand
J. P. Marquette
Youssef El Ahmad
Bruno Filoche-Romme
Laurent Schio
Carlos Garcia-Echeverria
Hélène Goulaouic
Benoit Pasquier

A small-molecule inhibitor of the type III phosphatidylinositol 3-kinase, Vps34, binds the ATP binding pocket and prevents vesicle trafficking and autophagy.

Keywords:

Biochemistry
Molecular biology
Vesicle
Small molecule
Phosphatidylinositol
Autophagy
Cell biology
Kinase
Biology
cancer therapy
binding pocket

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

285

Citations