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Luc Bertin

12

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190

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Optimization and Gram-scale Preparation of S-Trifluoromethyl- Sulfoximines and Sulfilimino iminiums, Powerful Reagents for the Late Stage Introduction of the CF3 Group

2019 Organic Process Research & Development
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Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.

2019 Journal of Medicinal Chemistry
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Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-Yl]-1-(3-Methyl-2-Oxobutyl)-2-(Trifluoromethyl)-3,4-Dihydro-2H-Pyrimido[1,2-A]Pyrimidin-6-One: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors.

2015 Journal of Medicinal Chemistry
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Preparation and optimization of new 4-(2-(indolin-1-yl)-2-oxoethyl)-2-morpholinothiazole-5-carboxylic acid and amide derivatives as potent and selective PI3Kβ inhibitors

2014 Bioorganic & Medicinal Chemistry Letters
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New indazole derivatives of hsp90 inhibitors, compositions containing them and use

2009
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New derivatives of carbazole of hsp90 inhibitors, compositions containing them and use

2008
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Nouveaux derives de 3-aryl-1 ,2-benzisoxazole, compositions les contenant et leur utilisation

2006
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New derivatives of isoindoles, compositions containing them, their preparation and their pharmaceutical uses such as inhibitors of activities of the protein chaperone hsp90

2005
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