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Fiorenza Falcioni

Hoffmann-La Roche

17

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Potent, selective MCH-1 receptor antagonists.

2008 Bioorganic & Medicinal Chemistry Letters
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Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity.

2003 Bioorganic & Medicinal Chemistry Letters
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SAR of Melanin-concentration Hormone (MCH), an Important Regulatory Hormone in Feeding Behavior

2001
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Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures.

2000 Journal of Medicinal Chemistry
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Peptidomimetic compounds that inhibit antigen presentation by autoimmune disease-associated class II major histocompatibility molecules

1999 Nature Biotechnology
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Binding affinity independent contribution of peptide length to the stability of peptide-HLA-DR complexes in live antigen presenting cells

1998 Human Immunology
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HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis.

1996 Journal of Experimental Medicine
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Influence of CD26 and integrins on the antigen sensitivity of human memory T cells

1996 Human Immunology
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Down-regulation of class II major histocompatibility complex molecules on antigen presenting cells after interaction with helper T cells

1995 European Journal of Immunology
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Down-regulation of class II major histocompatibility complex molecules on antigen-presenting cells by antibody fragments.

1995 European Journal of Immunology
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Citations (14)