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Jefferson Wright Tilley

Hoffmann-La Roche

124

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N-[ω-(Heteroaryl)Alkyl]Carboxamide Derivatives as Platelet Activating Factor Antagonists: Structure-Activity Relationships and Biological Data

2019
- Jefferson Wright Tilley
- Margaret O’Donnell
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Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia.

2014 Journal of Medicinal Chemistry
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Functionalized Organozinc Reagents in Medicinal Chemistry: Discovery of Novel Drug Candidates

2014 Synthesis
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Identification of N-acyl 4-(3-pyridonyl)phenylalanine derivatives and their orally active prodrug esters as dual acting α4β1 and α4β7 receptor antagonists.

2013 Bioorganic & Medicinal Chemistry Letters
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Identification of N-acyl 4-(5-pyrimidine-2,4-dionyl)phenylalanine derivatives and their orally active prodrug esters as dual-acting alpha4-beta1 and alpha4-beta7 receptor antagonists.

2013 Bioorganic & Medicinal Chemistry Letters
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Discovery of Orally Active Carboxylic Acid Derivatives of 2-Phenyl-5-trifluoromethyloxazole-4-carboxamide as Potent Diacylglycerol Acyltransferase-1 Inhibitors for the Potential Treatment of Obesity and Diabetes

2011 Journal of Medicinal Chemistry
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Discovery of novel and potent leukotriene B4 receptor antagonists. Part 1.

2010 Journal of Medicinal Chemistry
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The Direct Preparation of Protected Hydrazines from Alcohols via Mitsunobu Chemistry.

2010 ChemInform
- M. J. Di Grandi
- Jefferson Wright Tilley
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Structure activity of C-terminal modified analogs of Ac-CCK-7

2009 International Journal of Peptide and Protein Research
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Structure activity studies of tryptophan30 modified analogs of Ac‐CCK‐7

2009 International Journal of Peptide and Protein Research
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