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Ramakanth Sarabu

Hoffmann-La Roche

45

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Identification of RO4597014, a Glucokinase Activator Studied in the Clinic for the Treatment of Type 2 Diabetes.

2013 ACS Medicinal Chemistry Letters
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Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics

2012 American Journal of Physiology-endocrinology and Metabolism
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Repair of diverse diabetic defects of β‐cells in man and mouse by pharmacological glucokinase activation

2012 Diabetes, Obesity and Metabolism
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Inhibiteurs de ns5a de vhc

2012
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Thermal stabilty of glucokinase (GK) as influenced by the substrate glucose, an allosteric glucokinase activator drug (GKA) and the osmolytes glycerol and urea

2012 Biochimica et Biophysica Acta
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Discovery of benzothiazole-based adenosine A2B receptor antagonists with improved A2A selectivity

2011 Bioorganic & Medicinal Chemistry Letters
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Mutational analysis of allosteric activation and inhibition of glucokinase.

2011 Biochemical Journal
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2,3-Disubstituted acrylamides as potent glucokinase activators

2010 Bioorganic & Medicinal Chemistry Letters
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Discovery, Structure−Activity Relationships, Pharmacokinetics, and Efficacy of Glucokinase Activator (2R)-3-Cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide (RO0281675)

2010 Journal of Medicinal Chemistry
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4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: Drug-like and non-xanthine based A2B adenosine receptor antagonists

2010 Bioorganic & Medicinal Chemistry Letters
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