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Deepak Dalvie

Pfizer

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Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.

2017 Journal of Medicinal Chemistry
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Drug-Induced Liver Injury (DILI) Arising from Inhibition of Bile Acid Transport Proteins

2017
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Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate

2017 Journal of Medicinal Chemistry
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DEALING WITH REALITY

2016
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IN VITRO METHODS FOR EVALUATION OF DRUG METABOLISM

2016
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Cytochrome P450 and Non–Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics

2016 Drug Metabolism and Disposition
- Robert S. Foti
- Deepak Dalvie
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Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.

2016 Journal of Medicinal Chemistry
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Biotransformation and bioactivation reactions – 2015 literature highlights

2016 Drug Metabolism Reviews
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Metabolism of Xenobiotics by Aldehyde Oxidase

2015 Current protocols in immunology
- Deepak Dalvie
- Michael Zientek
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Metabolism, excretion and pharmacokinetics of [14C]crizotinib following oral administration to healthy subjects

2015 Xenobiotica
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Citations (36)