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Robert S. Foti

Amgen

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Pharmacokinetic and Drug Metabolism Properties of Novel Therapeutic Modalities

2019 Drug Metabolism and Disposition
- Brooke M. Rock
- Robert S. Foti
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Engineering NaV1.7 Inhibitory JzTx-V Peptides with a Potency and Basicity Profile Suitable for Antibody Conjugation To Enhance Pharmacokinetics

2019 ACS Chemical Biology
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Abstract 4484: Discovery and in vitro characterization of AMG 510–a potent and selective covalent small-molecule inhibitor of KRASG12C

2019 Cancer Research
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Abstract 3090:In vivocharacterization of AMG 510 - a potent and selective KRASG12Ccovalent small molecule inhibitor in preclinical KRASG12Ccancer models

2019 Cancer Research
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Correction to “Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement”

2017 ACS Medicinal Chemistry Letters
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選択的,状態依存Na_V1 7阻害剤としてのピペラジンアミドの発見およびhit‐to‐lead評価【Powered by NICT】

2017 MedChemComm
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Discovery and hit-to-lead evaluation of piperazine amides as selective, state-dependent NaV1.7 inhibitors

2017 MedChemComm
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Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors

2017 Bioorganic & Medicinal Chemistry Letters
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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities

2017 Journal of Medicinal Chemistry
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Comparison of the ligand binding site of CYP2C8 with CYP26A1 and CYP26B1: a structural basis for the identification of new inhibitors of the retinoic acid hydroxylases

2016 Journal of Enzyme Inhibition and Medicinal Chemistry
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