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Joyce J. Hwa

Schering-Plough

28

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1546

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The discovery of N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): a potent and selective glucagon receptor antagonist.

2014 Journal of Medicinal Chemistry
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Discovery of a potent thiadiazole class of histamine h3 receptor antagonist for the treatment of diabetes.

2012 ACS Medicinal Chemistry Letters
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Synthesis and structure-activity relationships of 2-(1,4'-bipiperidin-1'-yl)thiazolopyridine as H3 receptor antagonists.

2009 Bioorganic & Medicinal Chemistry Letters
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Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice.

2008 European Journal of Pharmacology
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Discovery of novel orally active ureido NPY Y5 receptor antagonists

2008 Bioorganic & Medicinal Chemistry Letters
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Dérivés de benzimidazole et leurs procédés d'utilisation

2008
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Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice

2006 European Journal of Pharmacology
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Traitement de la steatose hepatique non alcoolique au moyen d'agents hypocholesterolemiants et/ou dun agoniste inverse/antagoniste du recepteur h3

2006
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Energy Metabolic Profile of Mice after Chronic Activation of Central NPY Y1, Y2, or Y5 Receptors**

2005 Obesity Research
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Transgenic overexpression of neuromedin U promotes leanness and hypophagia in mice

2005 Journal of Endocrinology
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Citations (62)