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Jean E. Lachowicz

Schering-Plough

70

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2671

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Using ANG4043, a brain-penetrant anti-HER2 mab, to increase survival in a murine intracranial breast tumor model.

2017 Journal of Clinical Oncology
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Systemic administration of a brain-penetrant peptide–iduronidase conjugate results in brain IDUA activity in MPS I mice

2015 Molecular Genetics and Metabolism
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ANG4043, a Novel Brain-Penetrant Peptide–mAb Conjugate, Is Efficacious against HER2-Positive Intracranial Tumors in Mice

2015 Molecular Cancer Therapeutics
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Abstract 2465: Targeting HER2-positive brain metastases by incorporating the brain-penetrant Angiopep-2 peptide to an anti-HER2 antibody and anti-HER2 antibody drug conjugate

2015 Cancer Research
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Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties

2014 Journal of Clinical Investigation
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Abstract 2657: Utilization of the Angiopep platform to enable brain penetration of therapeutic mAbs or Antibody-Drug Conjugates for treatment of brain tumors

2014 Cancer Research
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Using the peptide angiopep-2 to create a GFP fusion protein with the ability to cross the blood-brain barrier and enter cells in the mouse brain

2014 Molecular Genetics and Metabolism
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The discovery of N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): a potent and selective glucagon receptor antagonist.

2014 Journal of Medicinal Chemistry
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Brain-penetrant lysosomal enzymes constructed by fusion with Angiopep-2, a unique LRP-1 binding peptide

2013 Molecular Genetics and Metabolism
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Abstract P6-11-05: ANG4043, a brain-penetrant anti-HER2 mAb increases survival in mice bearing intracranial BT-474 breast tumor cells

2013 Cancer Research
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