Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators
2011
Abstract We herein report the discovery of four series of fused 5,6-bicyclic heterocycles as γ-secretase modulators. Synthesis and SAR of these series are discussed. These compounds represent a new class of γ-secretase modulators that demonstrate moderate to good in vitro potency in inhibiting Aβ 42 production.
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