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Zhaoning Zhu

Merck & Co.

14

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281

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Discovery of potent iminoheterocycle BACE1 inhibitors.

2014 Bioorganic & Medicinal Chemistry Letters
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The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer’s disease

2013 Bioorganic & Medicinal Chemistry Letters
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Efficient synthesis and reaction pathway studies of novel fused morpholine oxadiazolines for use as gamma secretase modulators

2012 Tetrahedron Letters
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On the power of super acid—iodination of aromatic ring in the presence of imidazole moiety of the potent gamma secretase modulators (GSM) en route to tritium labeling

2012 Tetrahedron Letters
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Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators

2011 Bioorganic & Medicinal Chemistry Letters
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Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors

2011 Topics in Current Chemistry
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Structure and activity relationships of tartrate-based TACE inhibitors.

2010 Bioorganic & Medicinal Chemistry Letters
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Pharmacological characterization of novel iminoheterocyclic BACE1 inhibitors for the treatment of Alzheimer's disease

2010 Alzheimers & Dementia
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Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists

2010 Bioorganic & Medicinal Chemistry Letters
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