Emodin Increases Expression of Insulin-Like Growth Factor Binding Protein 1 through Activation of MEK/ERK/AMPKα and Interaction of PPARγ and Sp1 in Lung Cancer

Qing Tang,JingJing Wu,Fang Zheng,Swei Sunny Hann,YuQing Chen

Emodin Increases Expression of Insulin-Like Growth Factor Binding Protein 1 through Activation of MEK/ERK/AMPKα and Interaction of PPARγ and Sp1 in Lung Cancer

2017

Qing Tang
JingJing Wu
Fang Zheng
Swei Sunny Hann
YuQing Chen

Background: Emodin has anti-neoplastic activities on multiple tumors. However, the molecular mechanisms underlying this effect still remain to be fully understood

Keywords:

Multiple tumors
Biochemistry
Insulin-like growth factor-binding protein
MAPK/ERK pathway
Emodin
Diabetes mellitus
Pharmacology
Lung cancer
Biology
IGFBP1
Protein kinase A
Cell growth
Cell cycle
Sp1 transcription factor

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