Sp1 transcription factor

1SP1, 1SP2, 1VA1, 1VA2, 1VA3666720683ENSG00000185591ENSMUSG00000001280P08047O89090NM_001251825NM_003109NM_138473NM_013672NP_001238754NP_003100NP_612482NP_038700Transcription factor Sp1, also known as specificity protein 1* is a protein that in humans is encoded by the SP1 gene.1sp1: NMR STRUCTURE OF A ZINC FINGER DOMAIN FROM TRANSCRIPTION FACTOR SP1F3, MINIMIZED AVERAGE STRUCTURE1sp2: NMR STRUCTURE OF A ZINC FINGER DOMAIN FROM TRANSCRIPTION FACTOR SP1F2, MINIMIZED AVERAGE STRUCTURE1va1: Solution Structure of Transcription Factor Sp1 DNA Binding Domain (Zinc Finger 1)1va2: Solution Structure of Transcription Factor Sp1 DNA Binding Domain (Zinc Finger 2)1va3: Solution Structure of Transcription Factor Sp1 DNA Binding Domain (Zinc Finger 3) Transcription factor Sp1, also known as specificity protein 1* is a protein that in humans is encoded by the SP1 gene. The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. In the SV40 virus, Sp1 binds to the GC boxes in the regulatory region (RR) of the genome. SP1 belongs to the Sp/KLF family of transcription factors. The protein is 785 amino acids long, with a molecular weight of 81 kDa. The SP1 transcription factor contains a zinc finger protein motif, by which it binds directly to DNA and enhances gene transcription. Its zinc fingers are of the Cys2/His2 type and bind the consensus sequence 5'-(G/T)GGGCGG(G/A)(G/A)(C/T)-3' (GC box element). Sp1 has been used as a control protein to compare with when studying the increase or decrease of the aryl hydrocarbon receptor and/or the estrogen receptor, since it binds to both and generally remains at a relatively constant level. Plicamycin, an antineoplastic antibiotic produced by Streptomyces plicatus, and Withaferin A, a sterodial lactone from Withania somnifera plant are known to inhibit Sp1 transcription factor. Sp1 transcription factor has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.