IGFBP1

1ZT3, 1ZT5, 2DSQ348416006ENSG00000146678ENSMUSG00000020429P08833P47876NM_001013029NM_000596NM_008341NP_000587NP_032367Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.1zt3: C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid1zt5: C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid complexed with Iron(II)2dsq: Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene. This gene is a member of the Insulin-like growth factor-binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.