Rafał Kocyłowski

Polish Mother’s Memorial Hospital Research Institute

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Joanna Suliburska

University of Life Sciences in Poznań

Mariusz Grzesiak

Polish Mother’s Memorial Hospital Research Institute

Danuta Barałkiewicz

Adam Mickiewicz University in Poznań

Zuzanna Gaj

Polish Mother’s Memorial Hospital Research Institute

Constantin von Kaisenberg

Medizinische Hochschule Hannover

Ewa Bakinowska

Institute of Mathematics

Iwona Lewicka

University of Life Sciences in Poznań

Joanna Głowska-Ciemny

Jakub Pankiewicz

Adam Sajnóg

Adam Mickiewicz University in Poznań

Cooperative Institutions

University of Life Sciences in Poznań

Poznan University of Medical Sciences

Adam Mickiewicz University in Poznań

University of Life Sciences in Lublin

Polish Mother’s Memorial Hospital Research Institute

University of Łódź

Medical University of Lodz

Harris Birthright Research Centre for Fetal Medicine

University Hospital Schleswig-Holstein

University of Lübeck

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Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women

International Journal of Environmental Research and Public Health (2021)

Joanna Suliburska Agata Chmurzyńska Rafał Kocyłowski Katarzyna Skrypnik Anna Radziejewska

Although simultaneous supplementation of iron and folic acid is justified, the potential interactions between these micronutrients and other elements are poorly known. In this study, we aimed to investigate the effect of iron and folic acid supplementation on the levels of selected essential and toxic elements in the serum of micronutrient-deficient young women. A total of 40 women participated in this study and were divided into two groups: study group (n = 23) (with iron and folate deficiency) and control group (n = 17). The study group received iron and folic acid supplements for 3 months. Blood samples were collected at baseline and after the completion of the study period. Women completed a 3-day food intake record. We calculated the body mass index (BMI) of all the participants. Cellular morphology was analyzed in whole blood, and biochemical parameters were determined in serum. Elements were measured in serum by inductively coupled plasma mass spectrometry (ICP-MS). According to our results, in the case of the study group, the supplementation of iron and folic acid restored their levels; however, it caused a significant decrease in the level of zinc, calcium, and magnesium. In the case of the control group, at the end of the study period, there was a marked decrease in the level of iron. Interestingly, there was an increase in the level of arsenic and vanadium in both groups. In conclusion, simultaneous supplementation of iron and folic acid impairs the level of zinc, calcium, and magnesium in women of childbearing age.

10.3390/ijerph18031360

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Citations (9)

Evaluation of Essential and Toxic Elements in Amniotic Fluid and Maternal Serum at Birth

Biological Trace Element Research (2018)

Rafał Kocyłowski Mariusz Grzesiak Zuzanna Gaj Wiktor Lorenc Ewa Bakinowska

The objective of this study was to determine the concentration and the reference ranges of essential and toxic elements in amniotic fluid (AF) and maternal serum (MS) at birth. This study was conducted among 175 healthy pregnant Caucasian European women aged 18–42. AF and maternal blood samples were collected during delivery. An inductively coupled plasma mass spectrometry (ICP-MS) technique was used to determine the levels of Mg, Co, Cu, Zn, Sr, Cd, Ba, Pb, U, Ca, Cr, Al, Mn, V, Fe, As, Se and Sb in AF and MS. The range of reference values was calculated for all analyzed elements in the serum and AF. The mean concentrations of elements, except Pb, were generally higher in MS than in AF. Multiple regression analysis showed that the maternal/newborn body mass (MBM/NBM) ratio was a strong negative predictor (among maternal age and gravidity) of Mg concentration in amniotic fluid. In the serum, MBN/NBM ratio was a strong positive predictor of Cu concentration. Moreover, regression analysis showed that maternal age was an independent positive predictor of the Se level in maternal serum. The reference value ranges of 18 essential and toxic elements were established in AF and MS among a population of healthy pregnant Polish women at delivery. The level of Mg, Co, Cu, Ca and Se in AF and MS can be determined by maternal age and MBM/NBM ratio. These results can be useful in counseling individuals with pregnancies affected by exposure to one of the parameters under investigation.

Reference range

10.1007/s12011-018-1471-2

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Citations (16)

Hepatic aminotransferases of normal and IUGR fetuses in cord blood at birth

Early Human Development (2011)

Rafał Kocyłowski Mariusz Dubiel Sæmundur Gudmundsson Elfriede Fritzer Torvid Kiserud

Umbilical artery

Intrauterine growth restriction

Apgar score

Cord blood

10.1016/j.earlhumdev.2011.11.001

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Citations (12)

Nutrient Intake among Pregnant Women in Spain and Poland: A Comparative Analysis

Nutrients (2023)

Lucía Iglesias‐Vázquez Joanna Suliburska Rafał Kocyłowski Ewa Bakinowska Victoria Arija

Prenatal nutrition plays a crucial role in maternal and child health. This study aims to compare nutrient intake and its adequacy to recommendations among pregnant women in Spain and Poland. The ECLIPSES study in Spain utilized a self-administered food frequency questionnaire, while the PREDISH study in Poland employed a 3-day interview method. We assessed energy and nutrient intake against recommended dietary allowances. The analysis included 583 participants in the first trimester and 465 participants in the third trimester from both countries. Our findings revealed insufficient intake of iron, vitamin D, and vitamin B9 among pregnant women in both Spain and Poland. Significant differences were observed in the intake of energy, carbohydrates, fiber, calcium, iron, and vitamins D, E, C, B6, B9, and B12. Notably, 81.6% and 21.5% of participants did not meet the recommended minimum carbohydrate intake, while 99.8% and 43.8% exceeded the limit for total fat, particularly monounsaturated fatty acids (MUFAs). Tailored dietary guidance based on regional differences is crucial for pregnant women. Although variations in dietary intake were observed, both Spain and Poland faced similar risks of nutritional deficiencies, particularly for iron, vitamin D, and vitamin B9. These findings emphasize the need for enhanced efforts in preventing these deficiencies and promoting optimal prenatal nutrition.

Food frequency questionnaire

Dietary Reference Intake

10.3390/nu15143225

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Citations (3)

Selected trace elements concentrations in pregnancy and their possible role — literature review

Ginekologia Polska (2017)

Iwona Lewicka Rafał Kocyłowski Mariusz Grzesiak Zuzanna Gaj Przemysław Oszukowski

The aim of this study was to review the role of selected trace elements in pregnancy and fetal development. Citations related to the role of iron (Fe), zinc (Zn), manganese (Mn), copper (Cu) and selenium (Se) during pregnancy were searched in PubMed, Medline, Web of Science, using keywords and MeSH terms. Inadequate supply of trace elements can cause abnormalities of fetal development and predispose a child to disorders later on in life. Trace elements are the key elements of complex enzymes responsible for the modulation of the antioxidant defense system of the organism. It has been suggested that there is a correlation between reduced levels of trace elements essential for antioxidant function in the body of pregnant women, and an increased risk of developing preeclampsia. Trace elements are components of numerous regulatory enzymes and hormones essential to the division and differentiation of fetal cells and their further development. Mineral deficiencies in pregnant women can cause birth defects of the central nervous system, and growth disorders. Future research should be directed to explain the interaction between trace elements, and establish the optimum levels of macro and micronutrients supplementation, as well as determine the reference values for trace elements in the maternal serum, umbilical cord blood and amniotic fluid.

TRACE (psycholinguistics)

Trace metal

Trace element

10.5603/gp.a2017.0093

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Citations (73)

Association between the Concentrations of Essential and Toxic Elements in Mid-Trimester Amniotic Fluid and Fetal Chromosomal Abnormalities in Pregnant Polish Women

Diagnostics (2022)

Joanna Suliburska Jakub Pankiewicz Adam Sajnóg Magdalena Paczkowska Beata Nowakowska

The present study aimed to investigate the relationship between the concentrations of essential and toxic elements present in the amniotic fluid (AF) and fetal chromosomal abnormalities in pregnant women. A total of 156 pregnant white Polish women aged between 20 and 43 years and screened to detect high risk for chromosomal defects in the first trimester were included in the study. AF samples were collected from these women during routine diagnostic and treatment procedures at mid-gestation (15-22 weeks of their pregnancies). The concentrations of various minerals in the AF were determined by inductively coupled plasma mass spectrometry. Genomic hybridization and cytogenetic karyotyping were performed to detect chromosomal aberrations in the fetuses. The genetic analysis revealed chromosomal aberrations in 19 fetuses (over 12% of all the evaluated women). The major abnormalities identified were trisomy 21 (N = 11), trisomy 18 (N = 2), and triploidy (N = 2). Fetuses with chromosomal abnormalities more frequently showed lower manganese concentration in the AF in the second trimester as compared to those with normal karyotype. A coincidence was observed between high iron levels in the AF and a higher risk of chromosomal abnormalities in the fetuses.

Trisomy

Amniocentesis

10.3390/diagnostics12040979

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Citations (2)

Evaluation of Mineral Concentrations in Maternal Serum Before and After Birth and in Newborn Cord Blood Postpartum—Preliminary Study

Biological Trace Element Research (2017)

Rafał Kocyłowski Iwona Lewicka Mariusz Grzesiak Zuzanna Gaj Przemysław Oszukowski

Cord blood

Umbilical artery

10.1007/s12011-017-1109-9

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Citations (18)

Relationship between pre-pregnancy body mass index and mineral concentrations in serum and amniotic fluid in pregnant women during labor

Journal of Trace Elements in Medicine and Biology (2018)

Iwona Lewicka Rafał Kocyłowski Mariusz Grzesiak Zuzanna Gaj Adam Sajnóg

Underweight

Blood serum

10.1016/j.jtemb.2018.12.007

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Citations (13)

Referenzwerte für Marker hypoxischer Herzschädigung aus arteriellem und venösem Nabelschnurblut normaler Neugeborener

Zeitschrift für Geburtshilfe und Neonatologie (2005)

Rafał Kocyłowski Breborowicz Gh I Sieg Elfriede Fritzer C. v. Kaisenberg

Das Wohlbefinden Neugeborener wird heute postpartal meist durch Nabelschnurblutgase, APGAR Scores und zusätzliche Tests beschrieben. Diese Untersuchungen zielen darauf ab, zu dokumentieren, dass das zentrale Nervensystem unter der Geburt keinen Schaden erlitten hat.

10.1055/s-2005-923275

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Citations (0)

A new procedure for the determination of 21 macro- and trace elements in human fetal urine using an inductively coupled plasma mass spectrometry with dynamic reaction cell (ICP-DRC-MS) equipped with a micro-flow nebulizer

Talanta (2020)

Adam Sajnóg Marcin Tkaczyk Małgorzata Stańczyk Krzysztof Szaflik Joanna Suliburska

Certified reference materials

Microwave digestion

Matrix (chemical analysis)

10.1016/j.talanta.2020.121672

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Citations (9)