Hepatic aminotransferases of normal and IUGR fetuses in cord blood at birth
Rafał KocyłowskiMariusz DubielSæmundur GudmundssonElfriede FritzerTorvid KiserudConstantin von Kaisenberg
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Keywords:
Umbilical artery
Intrauterine growth restriction
Apgar score
Cord blood
We present a 37-week female baby, known with intrauterine growth restriction since 25 weeks of pregnancy, born with a placenta with an excessive long umbilical cord (ELUC), without any other abnormalities. ELUC is mostly an incidental finding after delivery, but represents a potentially detectable intrauterine cause of growth restriction. A system that allows ultrasound measurement of the length of the umbilical cord could highly increase antenatal diagnosis of ELUC.
Intrauterine growth restriction
Growth restriction
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Umbilical cord blood is an important graft source in the treatment of many genetic, hematologic, and immunologic disorders by hematopoietic stem cell transplantation. Millions of cord blood units have been collected and stored for clinical use since the inception of cord blood banking in 1989. However, the use of cord blood in biomedical research has been limited by access to viable samples. Here, we present a cost-effective, self-sustaining model for the procurement of fresh umbilical cord blood components for research purposes within hospital-affiliated academic institutions.
Cord blood
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In a retrospective study data from more than 9000 live births were analyzed. Our aim was to compare the significance of Apgar-Score and umbilical artery pH in predicting the condition and development of the newborn. We were particularly interested in three groups of patients: "Group A" included patients with a 5 minute Apgar-Score < or = 7 and a normal pH > 7,2. In "Group P" the pH was < 7,10 combined with a normal Apgar-Score (8 to 10). Both groups were compared with a "normal group" (pH > 7,20 and Apgar-Score between 8 and 10). There was a higher percentage of operative deliveries in group A (38%) and group P (20%) compared to the normal group (15%). The only predictor of a low Apgar-Score was meconium stained amniotic fluid (Group A 16%). A poor condition of the newborn correlated much better with a low Apgar-Score than with a low umbilical artery pH. In group A the rate of newborns transferred to the neonatology unit was 43% and the perinatal mortality rate was 50%. The poor correlation of a low umbilical artery pH and the fetal outcome is partly explainable by the standard cut off level of 7,20 for acidosis, which seems to be too high.
Umbilical artery
Apgar score
Neonatology
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Umbilical artery
Base excess
Arterial blood
Arterial pH
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Background: As the new born is delivered and the umbilical cord divided, blood can be collected from the segment of cord, still attached to the placenta are known as “umbilical cord blood” stem cell. The blood collected in the umbilical cord is said to be a rich origin of stem. The blood contains stem cells which are also known as hematopoietic cells and these cells can convert into any types of organs in the body. These stem cells collected from the umbilical cord can heal genetic diseases related to blood and immune system like cancer, blood disorders and several life –threatening diseases. Objectives: Assess the level of knowledge regarding stem cells and cord blood banking among antenatal mothers. Find out the association between the level of knowledge regarding stem cells and cord blood banking among antenatal mothers with their selected demographic variables.
Cord blood
Placenta cord banking
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The study was aimed to establish a standard procedure for human umbilical cord blood bank. The hematopoietic nucleated cells in cord blood were processed by using sedimentation and centrifugation method. After finishing CD34(+) cell counting, hematopoietic progenitor cell assay, microbial culture, infectious disease test and HLA typing, cord blood units were stored in the liquid nitrogen for further application. The results showed that nucleated cells of cord blood were (10.94 +/- 2.74) x 10(8) per unit; recovery rate of nucleated cells was (79.82 +/- 17.76)%. CD34(+) cells in cord blood were counted as (51.62 +/- 30.53) x 10(5) per unit. Eight units of cord blood were thawed after two years of cryopreservation, the recovery rate of nucleated cells, CD34(+) cells and CFU-GM were (91.4 +/- 6.0)%, (84.6 +/- 20.0)% and (85.8 +/- 14.9)% respectively. It is suggested that the methods and procedure reported for processing and cryopreservation of hematopoietic stem/progenitor cells in the human umbilical cord blood is effective.
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To find out the influence of nuchal cord on neonatal acid-base balance we obtained 117 umbilical artery blood samples from full-term newborns immediately after cord clamping. In 29 cases umbilical cord entanglement was observed while delivery. For each case we matched control case with basic obstetrical factors comparable. In those two groups no significant difference between mean values of acid-base balance parameters was found.
Umbilical artery
Acid–base homeostasis
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Umbilical artery
Single umbilical artery
Aplasia
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Cord blood
Placenta cord banking
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