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Astrid Bottelbergs

Janssen Pharmaceutica

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CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia.

2021 Acta neuropathologica communications
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Passive immunotherapy with a novel antibody against 3pE-modified Aβ demonstrates potential for enhanced efficacy and favorable safety in combination with BACE inhibitor treatment in plaque-depositing mice.

2021 Neurobiology of Disease
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Time Trends of Cerebrospinal Fluid Biomarkers of Neurodegeneration in Idiopathic Normal Pressure Hydrocephalus

2021 Journal of Alzheimer's Disease
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Discovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody

2020 Journal of Alzheimer's Disease
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Neural oscillations during cognitive processes in an App knock-in mouse model of Alzheimer’s disease pathology

2019 Scientific Reports
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Anti-Tau Monoclonal Antibodies Derived from Soluble and Filamentous Tau Show Diverse Functional Properties in vitro and in vivo

2018 Journal of Alzheimers Disease
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Diffusion kurtosis imaging allows the early detection and longitudinal follow-up of amyloid-β-induced pathology

2018 Alzheimer's Research & Therapy
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S-[ 18F]THK-5117-PET and [ 11C]PIB-PET Imaging in Idiopathic Normal Pressure Hydrocephalus in Relation to Confirmed Amyloid-β Plaques and Tau in Brain Biopsies

2018 Journal of Alzheimer's Disease
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Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer’s disease pathology

2017 Scientific Reports
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[18F]THK-5117-PET AND [11C]PIB-PET IMAGING IN IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS (INPH) IN RELATION TO CONFIRMED AMYLOID-β PLAQUES AND TAU IN BRAIN BIOPSIES

2017 Alzheimers & Dementia
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